Somatic POLE mutations cause an ultramutated giant cell high-grade glioma subtype with better prognosis


Erson-Omay E. Z. , Caglayan A. O. , Schultz N., Weinhold N., Omay S. B. , ÖZDUMAN K., ...More

NEURO-ONCOLOGY, vol.17, no.10, pp.1356-1364, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 10
  • Publication Date: 2015
  • Doi Number: 10.1093/neuonc/nov027
  • Title of Journal : NEURO-ONCOLOGY
  • Page Numbers: pp.1356-1364

Abstract

Background. Malignant high-grade gliomas (HGGs), including the most aggressive form, glioblastoma multiforme, show significant clinical and genomic heterogeneity. Despite recent advances, the overall survival of HGGs and their response to treatment remain poor. In order to gain further insight into disease pathophysiology by correlating genomic landscape with clinical behavior, thereby identifying distinct HGG molecular subgroups associated with improved prognosis, we performed a comprehensive genomic analysis.