Reversible conduction failure in overlap of Miller Fisher syndrome and pharyngeal-cervical-brachial variant of Guillain-Barre syndrome in the spectrum of nodo-paranodopathies

Gursoy A. E. , Kolukisa M. , BABACAN-YILDIZ G. , ALTINTAS O., YAMAN A., Asil T.

JOURNAL OF CLINICAL NEUROSCIENCE, cilt.21, sa.7, ss.1269-1271, 2014 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 21 Konu: 7
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1016/j.jocn.2013.10.022
  • Sayfa Sayıları: ss.1269-1271


Patients with an overlap of the pharyngeal-cervical-brachial variant of Guillain-Barre syndrome and Miller Fisher syndrome (PCB/MFS) have rarely been reported. The electrophysiological findings in PCB/MFS are of great interest and may provide insight into the pathophysiology of the disorder. We report the clinical features and nerve conduction study findings in a patient with PCB/MFS with high titers of antiganglioside antibodies against GQ1b, GD1a, and GD1b. In serial nerve conduction studies, compound muscle action potential amplitudes normalised without development of temporal dispersion within 3 weeks, and absent median, ulnar, and sural sensory nerve action potentials became recordable within 4 months. These findings are consistent with reversible conduction failure in both motor and sensory fibres, and PCB/MFS could be classified in the recently described nodo-paranodopathy spectrum of acute neuropathies associated with anti-ganglioside antibodies. (c) 2013 Elsevier Ltd. All rights reserved.