Synthesis of new derivatives of 1-(3-aminophenyl)-4-benzoyl-5-phenyl-1H-pyrazole-3-carboxylic acid


Kasimogullari R., Zengin B. , Maden M., Mert S., KAZAZ C.

JOURNAL OF THE SERBIAN CHEMICAL SOCIETY, vol.75, no.12, pp.1625-1635, 2010 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 75 Issue: 12
  • Publication Date: 2010
  • Doi Number: 10.2298/jsc101018135k
  • Title of Journal : JOURNAL OF THE SERBIAN CHEMICAL SOCIETY
  • Page Numbers: pp.1625-1635

Abstract

1-(3-Aminophenyl)-4-benzoyl-5-phenyl-1H-pyrazole-3-carboxylic acid (1) was synthesized according to the literature.(1) 2-(3-Aminophenyl)-2,6-dihydro-3,4-diphenyl-7H-pyrazolo[3,4-d]pyridazin-7-one (5) was obtained by the cyclocondensation reaction of 1 with hydrazine hydrate. New pyrazole derivatives of compounds 1 and 5 were synthesized by their reaction with beta-diketones, beta-ketoesters, beta-naphthol, phenol and various other reagents. The structures of the synthesized compounds were characterized by (1)H-NMR, (13)C-NMR, IR and mass spectroscopy, as well as elemental analysis.