What are optimum target levels of hemoglobin in older adults?

Kara O., Soysal P., Smith L., Kiskac M.

Aging clinical and experimental research, vol.33, no.12, pp.3173-3181, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 12
  • Publication Date: 2021
  • Doi Number: 10.1007/s40520-021-01854-7
  • Journal Name: Aging clinical and experimental research
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Abstracts in Social Gerontology, AgeLine, CAB Abstracts, CINAHL, EMBASE, MEDLINE
  • Page Numbers: pp.3173-3181
  • Keywords: Anemia, Hemoglobin, Geriatric assessment, Elderly, ANEMIA, ASSOCIATION, FALLS, DEPRESSION, CAPACITY, RISK
  • Bezmialem Vakıf University Affiliated: Yes


Aim The aim of this study is to identify optimum target levels of hemoglobin (Hgb) in older males and females according to cognitive performance, mood state, nutrition intake, balance-walking functions, muscle strength and performance in daily life activities. Method A total of 1942 geriatric patients who had undergone comprehensive geriatric assessment were evaluated. The patient's demographic characteristics, comorbid diseases, number of drugs, cognitive performance, mood and nutritional states, basic and instrumental daily living activity indexes were obtained from hospital files. Hgb levels were analyzed on the same day. Receiver Operating Characteristic analysis was used to detect the optimum level of Hgb according to the best performance of geriatric assessment parameters. Results 1095 participants took part of who 71.9% were female and the mean age was 76.92 +/- 7.38 years (65-103 years). There was a significant negative correlation between age, number of drugs used, Geriatric Depression Scale-15, Timed Up and Go test and Hgb in both sexes while a significant positive correlation was found between Barthel and Lawton activities of daily living, Tinetti test, Mini Nutritional Assessment, Mini-Mental State Examination and Hgb (p < 0.05). The optimum Hgb levels were >= 13.0 for females and >= 13.9 in males. Conclusion Findings from the present study in relation to Hgb and key geriatric evaluation parameters suggests that the optimum level of Hgb for older females and males is higher than the level of Hgb in current definitions. Data from this study suggest that the optimum value of the Hgb level is 13.0 for females and 13.9 for males.