Prognostic significance of protein kinase B/Akt pathway in patients with non-small cell lung cancer


Mayadagli A. , Gul S. K. , Bilici A., Oruc A. F. , Kocak M., Ozkan A., ...Daha Fazla

JOURNAL OF BUON, cilt.19, sa.1, ss.157-163, 2014 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19 Konu: 1
  • Basım Tarihi: 2014
  • Dergi Adı: JOURNAL OF BUON
  • Sayfa Sayıları: ss.157-163

Özet

Purpose: Akt, also known as protein kinase B (PKB), is an intracellular signal transduction protein activated by growth hormones. PKB/Akt is frequently activated in a variety of cancer types, but its role in the development and progression of lung cancer has not been completely elucidated yet. The aim of the present study was to determine the prognostic value of PKB/Akt in non-small cell lung cancer (NSCLC).