Prognostic significance of protein kinase B/Akt pathway in patients with non-small cell lung cancer

Mayadagli A., Gul S. K., Bilici A., Oruc A. F., Kocak M., Ozkan A., ...More

JOURNAL OF BUON, vol.19, no.1, pp.157-163, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 1
  • Publication Date: 2014
  • Journal Name: JOURNAL OF BUON
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.157-163
  • Bezmialem Vakıf University Affiliated: Yes

Abstract

Purpose: Akt, also known as protein kinase B (PKB), is an intracellular signal transduction protein activated by growth hormones. PKB/Akt is frequently activated in a variety of cancer types, but its role in the development and progression of lung cancer has not been completely elucidated yet. The aim of the present study was to determine the prognostic value of PKB/Akt in non-small cell lung cancer (NSCLC).