Analysis of viral diversity for vaccine target discovery


Khan A. M. , Hu Y., Miotto O., Thevasagayam N. M. , Sukumaran R., Raman H. S. A. , ...More

BMC MEDICAL GENOMICS, vol.10, 2017 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 10
  • Publication Date: 2017
  • Doi Number: 10.1186/s12920-017-0301-2
  • Title of Journal : BMC MEDICAL GENOMICS
  • Keywords: Viral diversity, Bioinformatics, Vaccine design, Target discovery, Reverse vaccinology, Database, Tools, T-CELL EPITOPES, MULTIPLE SEQUENCE ALIGNMENT, MHC CLASS-I, LYMPHOCYTE RESPONSES, COMPUTATIONAL SYSTEM, HLA-A, DENGUE, PREDICTION, BINDING, DATABASE

Abstract

Background: Viral vaccine target discovery requires understanding the diversity of both the virus and the human immune system. The readily available and rapidly growing pool of viral sequence data in the public domain enable the identification and characterization of immune targets relevant to adaptive immunity. A systematic bioinformatics approach is necessary to facilitate the analysis of such large datasets for selection of potential candidate vaccine targets.