Management of pediatric cardiac transplantation candidates with pulmonary hypertension and high pulmonary vascular resistance.

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Yakut K., Varan B., Erdoğan İ., Cindik N., Gökdemir M., Gümüş A., ...More

The Turkish journal of pediatrics, vol.62, pp.461-467, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 62
  • Publication Date: 2020
  • Doi Number: 10.24953/turkjped.2020.03.013
  • Journal Name: The Turkish journal of pediatrics
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.461-467
  • Keywords: cardiac transplantation, pulmonary hypertension, pulmonary vascular resistance, right ventricular failure, INHALED NITRIC-OXIDE, HEART-TRANSPLANTATION, FAILURE, MORTALITY, REVERSIBILITY, ADENOSINE, INFUSION, CHILDREN, IMPACT, INDEX
  • Bezmialem Vakıf University Affiliated: Yes

Abstract

Background and objectives. Right ventricular failure is an important cause of mortality and morbidity after orthotopic heart transplantation (OHT). The right ventricle of the donor may fail to accommodate to the high pulmonary vascular resistance (PVR) of the recipient. Pulmonary hypertension (PH) due to chronic heart failure with PVRi > 4 Wood units.m(2), transpulmonary gradient > 15 mmHg adversely affect the outcome of OHT. In this study we aimed to evaluate management strategies in our pediatric cardiac transplantation candidates with PH and high PVR prior to OHT.