Role of cathepsin D activation in major adverse cardiovascular events and new-onset heart failure after STEMI

YAMAÇ A. H. , Sevgili E., Kucukbuzcu S., Nasifov M., Ismailoglu Z., Kilic E., et al.

HERZ, cilt.40, no.6, ss.912-919, 2015 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 40 Konu: 6
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1007/s00059-015-4311-6
  • Dergi Adı: HERZ
  • Sayfa Sayısı: ss.912-919


Increased serum levels of the activated aspartic lysosomal endopeptidase cathepsin D (CatD) have been found in patients with acute myocardial infarction (AMI). However, to date there have been no analyses of clinical follow-up data measuring the enzyme course and its role in the development of post-MI heart failure. This study aimed to evaluate the role of serum CatD activity in the development of heart failure in patients with ST-segment elevation acute myocardial infarction (STEMI).