Role of cathepsin D activation in major adverse cardiovascular events and new-onset heart failure after STEMI

YAMAÇ, AYLİN; Sevgili, Emrah; Kucukbuzcu, Sitki; Nasifov, Muharrem; Ismailoglu, Ziya; Kilic, Elif; Ercan, ÇİLEM; Jafarov, Parviz; Uyarel, Huseyin; BACAKSIZ, AHMET

doi:10.1007/s00059-015-4311-6

Role of cathepsin D activation in major adverse cardiovascular events and new-onset heart failure after STEMI

YAMAÇ A. H., Sevgili E., Kucukbuzcu S., Nasifov M., Ismailoglu Z., Kilic E., ...Daha Fazla

HERZ, cilt.40, sa.6, ss.912-919, 2015 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 40 Sayı: 6
Basım Tarihi: 2015
Doi Numarası: 10.1007/s00059-015-4311-6
Dergi Adı: HERZ
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.912-919
Bezmiâlem Vakıf Üniversitesi Adresli: Evet

Özet

Increased serum levels of the activated aspartic lysosomal endopeptidase cathepsin D (CatD) have been found in patients with acute myocardial infarction (AMI). However, to date there have been no analyses of clinical follow-up data measuring the enzyme course and its role in the development of post-MI heart failure. This study aimed to evaluate the role of serum CatD activity in the development of heart failure in patients with ST-segment elevation acute myocardial infarction (STEMI).