Role of cathepsin D activation in major adverse cardiovascular events and new-onset heart failure after STEMI

YAMAÇ A. H., Sevgili E., Kucukbuzcu S., Nasifov M., Ismailoglu Z., Kilic E., ...More

HERZ, vol.40, no.6, pp.912-919, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 40 Issue: 6
  • Publication Date: 2015
  • Doi Number: 10.1007/s00059-015-4311-6
  • Journal Name: HERZ
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.912-919
  • Bezmialem Vakıf University Affiliated: Yes

Abstract

Increased serum levels of the activated aspartic lysosomal endopeptidase cathepsin D (CatD) have been found in patients with acute myocardial infarction (AMI). However, to date there have been no analyses of clinical follow-up data measuring the enzyme course and its role in the development of post-MI heart failure. This study aimed to evaluate the role of serum CatD activity in the development of heart failure in patients with ST-segment elevation acute myocardial infarction (STEMI).