The cytokine response in THP-1 (monocyte) and HL-60 (neutrophil-differentiated) cells infected with different genotypes of Helicobacter pylori strains


Caliskan R., Yazgan A. S. , Tokman H. B. , Sofyali E., Erzin Y. Z. , Akgul O., et al.

TURKISH JOURNAL OF GASTROENTEROLOGY, cilt.26, ss.297-303, 2015 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 26 Konu: 4
  • Basım Tarihi: 2015
  • Doi Numarası: 10.5152/tjg.2015.8058
  • Dergi Adı: TURKISH JOURNAL OF GASTROENTEROLOGY
  • Sayfa Sayısı: ss.297-303

Özet

Background/Aims: Helicobacter pylori (H. pylori) is a microaerophilic bacterium related with peptic ulcer and gastric cancer. Its virulence factors include cytotoxin-associated gene A (CagA) and vacuolating cytotoxin gene A (VacA) proteins. Cytokine release inducted by H. pylori colonization has an important role in pathogenesis of H. pylori. The severity of gastric pathologies depends on the H. pylori genotypes found in different geographical regions. We aimed to determine the relationship between different H. pylori genotypes and their effects on the cytokine release levels.