Flavonoid constituents of Sideritis caesarea

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Halfon B., Ciftci E., Topcu G.

TURKISH JOURNAL OF CHEMISTRY, vol.37, no.3, pp.464-472, 2013 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 37 Issue: 3
  • Publication Date: 2013
  • Doi Number: 10.3906/kim-1206-45
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.464-472
  • Keywords: Penduletin, methoxyflavones, flavone glycosides, Sideritis caesarea, anticholinesterase activity, Lamiaceae, ENT-KAURANE DITERPENOIDS, PHENOLIC-COMPOUNDS, TURKEY, ANTIOXIDANT, GLYCOSIDES, PLANTS
  • Bezmialem Vakıf University Affiliated: Yes


The acetone extract of the aerial parts of Sideritis caesarea Duman, Aytac & Baser (Lamiaceae) afforded the flavonoids penduletin (1) and apigenin (2) and 6 glycosylated flavonoids, 4'-O-methyl-isoscutellarein-7-O-[6 '''-O-acetyl-beta-D-allopyranosyl-(1 -> 2)]-6 ''-O-acetyl-beta-D-glucopyranoside (3), 4'-O-methylhypolaetin-7-O-[6 '''-O-acetyl-beta-D-allopyranosyl-(1 -> 2)]-6 ''-O-acetyl-beta-D-glucopyranoside (4), isoscutellarein-7-O-[6 '''-O-acetyl-beta-D-allopyranosyl-(1 -> 2)]-6 ''-O-acetyl-beta-D-glucopyranoside (5), isoscutellarein-7-O-[6 '''-O-acetyl-beta-D-allopyranosyl-(1 -> 2)]-beta-D-glucopyranoside (6), 4'-O-methylhypolaetin-7-O-[6 '''-O-acetyl-beta-D-allopyranosyl-(1 -> 2)]-beta-D-glucopyranoside (7), and hypolaetin-7-O-[6 '''-O-acetyl-beta-D-allopyranosyl-(1 -> 2)]-beta-D-glucopyranoside (8). The compounds were identified by the use of 1D- and 2D-NMR and UV spectroscopic techniques and by comparisons with the reported data. The acetyl-cholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities of the acetone, methanol, and water extracts of the plant and of the flavones penduletin and apigenin were evaluated at 200 mu g/mL. The water extract exhibited better activity against the enzyme AChE as compared to both the acetone and the methanol extracts. Penduletin (1) showed significant activity against BChE (66.58%) while apigenin (2) showed weak activity against both enzymes.