Effects of resveratrol in inflammatory arthritis

Elmali N., BAYSAL O., HARMA A., ESENKAYA I., MIZRAK B.

INFLAMMATION, vol.30, pp.1-6, 2007 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 30
  • Publication Date: 2007
  • Doi Number: 10.1007/s10753-006-9012-0
  • Journal Name: INFLAMMATION
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1-6
  • Bezmialem Vakıf University Affiliated: No

Abstract

Nuclear factor kappa B (NF-kappa B), is a pivotal transcription factor involved in the activation of the TNF-alpha and IL-1 beta genes. Activation of NF-kappa B in synovial cells is a feature seen in arthritis patients. Resveratrol, a polyphenolic, natural phytoalexin found with particularly high levels in grape skin and red wine is potent and specific inhibitor of TNF-alpha and IL-1 beta induced NF-kappa B activation. We aimed to determine the in vivo effects of intra-articular injections of resveratrol on cartilage and synovium in an experimental rabbit inflammatory arthritis model.