Efficacy of interferon alpha-2b and lamivudine combination treatment in comparison to interferon alpha-2b alone in chronic delta hepatitis: A randomized trial

Canbakan, B; Senturk, HAKAN; TABAK, Ömer; Akdogan, M; Tahan, V; Mert, A; Sut, N; Ozaras, R; Midilli, K; Ozbay, G

doi:10.1111/j.1440-1746.2006.04082.x

Efficacy of interferon alpha-2b and lamivudine combination treatment in comparison to interferon alpha-2b alone in chronic delta hepatitis: A randomized trial

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Canbakan B., Senturk H., TABAK Ö. F., Akdogan M., Tahan V., Mert A., ...More

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, vol.21, no.4, pp.657-663, 2006 (SCI-Expanded)

Publication Type: Article / Article
Volume: 21 Issue: 4
Publication Date: 2006
Doi Number: 10.1111/j.1440-1746.2006.04082.x
Journal Name: JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.657-663
Bezmialem Vakıf University Affiliated: Yes

Abstract

Background and Aim: Delta hepatitis is characterized by rapidly progressive liver disease with adverse prognosis in most patients. Patients benefit from high doses and prolonged courses of interferon (IFN) therapy; however, lamivudine as a single agent has been disappointing. Data relating to the efficacy of IFN and lamivudine in combination is limited. The aim of this study was to test the efficacy of IFN-alpha 2b and lamivudine combination treatment in comparison to IFN-alpha 2b alone in patients with chronic delta hepatitis.