Efficacy of interferon alpha-2b and lamivudine combination treatment in comparison to interferon alpha-2b alone in chronic delta hepatitis: A randomized trial

Canbakan B., Senturk H., TABAK Ö. F., Akdogan M., Tahan V., Mert A., ...More

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, vol.21, no.4, pp.657-663, 2006 (SCI-Expanded) identifier identifier identifier


Background and Aim: Delta hepatitis is characterized by rapidly progressive liver disease with adverse prognosis in most patients. Patients benefit from high doses and prolonged courses of interferon (IFN) therapy; however, lamivudine as a single agent has been disappointing. Data relating to the efficacy of IFN and lamivudine in combination is limited. The aim of this study was to test the efficacy of IFN-alpha 2b and lamivudine combination treatment in comparison to IFN-alpha 2b alone in patients with chronic delta hepatitis.