Therapeutic vaccination in chronic hepatitis B

Senturk H., TABAK Ö. F., Akdogan M., Erdem L., Mert A., Ozaras R., ...More

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, vol.17, no.1, pp.72-76, 2002 (SCI-Expanded) identifier identifier identifier


Aims: The aim was to test the efficacy of a pre-S2-containing vaccine (Genhevac-B) in chronic hepatitis B (CHB). Twenty-five naive patients (22 male, three female; median age 35; range: 6-69 years) with CHB were recruited. The inclusion criteria were: hepatitis B e antigen (HBeAg) positive or HBV-DNA detectable with liquid hybridization; alanine aminotransferase (ALT) is at least 1.5-fold the upper normal limit and histological evidence of chronic hepatitis.