Therapeutic vaccination in chronic hepatitis B

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Senturk H., TABAK Ö. F., Akdogan M., Erdem L., Mert A., Ozaras R., ...More

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, vol.17, no.1, pp.72-76, 2002 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 17 Issue: 1
• Publication Date: 2002
• Doi Number: 10.1046/j.1440-1746.2002.02652.x
• Journal Name: JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.72-76
• Bezmialem Vakıf University Affiliated: Yes

Abstract

Aims: The aim was to test the efficacy of a pre-S2-containing vaccine (Genhevac-B) in chronic hepatitis B (CHB). Twenty-five naive patients (22 male, three female; median age 35; range: 6-69 years) with CHB were recruited. The inclusion criteria were: hepatitis B e antigen (HBeAg) positive or HBV-DNA detectable with liquid hybridization; alanine aminotransferase (ALT) is at least 1.5-fold the upper normal limit and histological evidence of chronic hepatitis.