Therapeutic vaccination in chronic hepatitis B


Senturk H. , TABAK Ö. F. , Akdogan M., Erdem L., Mert A., Ozaras R., ...More

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, vol.17, no.1, pp.72-76, 2002 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 1
  • Publication Date: 2002
  • Doi Number: 10.1046/j.1440-1746.2002.02652.x
  • Title of Journal : JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
  • Page Numbers: pp.72-76

Abstract

Aims: The aim was to test the efficacy of a pre-S2-containing vaccine (Genhevac-B) in chronic hepatitis B (CHB). Twenty-five naive patients (22 male, three female; median age 35; range: 6-69 years) with CHB were recruited. The inclusion criteria were: hepatitis B e antigen (HBeAg) positive or HBV-DNA detectable with liquid hybridization; alanine aminotransferase (ALT) is at least 1.5-fold the upper normal limit and histological evidence of chronic hepatitis.