Angiotensin-I-Converting Enzyme (ACE)-Inhibitory Peptides from Plants

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Daskaya-Dikmen C., Yucetepe A., Karbancioglu-Guler F., Daşkaya H., Özçelik B.

NUTRIENTS, vol.9, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 9
  • Publication Date: 2017
  • Doi Number: 10.3390/nu9040316
  • Journal Name: NUTRIENTS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: angiotensin-I-converting enzyme inhibitory activity, bioactive peptides, plant proteins, enzymatic hydrolysis, bioavailability, obesity, diabetes, ACE-INHIBITORY PEPTIDES, WHEAT-GERM PROTEIN, BIOACTIVE PEPTIDES, ANTIHYPERTENSIVE PEPTIDES, TRANSEPITHELIAL TRANSPORT, VITRO DIGESTION, STRUCTURAL REQUIREMENTS, ANTIOXIDANT PROPERTIES, BACILLUS-SUBTILIS, BLOOD-PRESSURE
  • Bezmialem Vakıf University Affiliated: Yes

Abstract

Hypertension is an important factor in cardiovascular diseases. Angiotensin-I-converting enzyme (ACE) inhibitors like synthetic drugs are widely used to control hypertension. ACE-inhibitory peptides from food origins could be a good alternative to synthetic drugs. A number of plant-based peptides have been investigated for their potential ACE inhibitor activities by using in vitro and in vivo assays. These plant-based peptides can be obtained by solvent extraction, enzymatic hydrolysis with or without novel food processing methods, and fermentation. ACE-inhibitory activities of peptides can be affected by their structural characteristics such as chain length, composition and sequence. ACE-inhibitory peptides should have gastrointestinal stability and reach the cardiovascular system to show their bioactivity. This paper reviews the current literature on plant-derived ACE-inhibitory peptides including their sources, production and structure, as well as their activity by in vitro and in vivo studies and their bioavailability.