VEGF-A and FGF gene therapy accelerate healing of ischemic colonic anastomoses (experimental study)

Adas G., Percem A., Adas M., Kemik O., Arikan S., Ustek D., ...Daha Fazla

INTERNATIONAL JOURNAL OF SURGERY, cilt.9, sa.6, ss.467-471, 2011 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 9 Sayı: 6
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1016/j.ijsu.2011.05.002
  • Dergi Adı: INTERNATIONAL JOURNAL OF SURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.467-471
  • Anahtar Kelimeler: Ischemic colon anastomosis, Growth factors, Wound healing, COLLAGEN DEPOSITION, HEPARAN-SULFATE, GROWTH-FACTORS, ANGIOGENESIS, STRENGTH, SAFETY
  • Bezmiâlem Vakıf Üniversitesi Adresli: Hayır

Özet

Background: Reducing ischemic damage is one of the goals of surgery. The aim of this study was to apply human VEGF-A and FGF-2 DNA-mediated gene therapy in order to identify their effects in the healing of ischemic colon anastomoses and eliminating the negative effects of ischemia.