VEGF-A and FGF gene therapy accelerate healing of ischemic colonic anastomoses (experimental study)

Adas, Gokhan; Percem, Askin; Adas, Mine; Kemik, Ozgur; Arikan, Soykan; Ustek, Duran; Cakiris, Aris; Abaci, Neslihan; Kemik, Ahu; Kamali, Gulcin; Karahan, Servet; Akcakaya, Adem; Karatepe, Oguzhan

doi:10.1016/j.ijsu.2011.05.002

VEGF-A and FGF gene therapy accelerate healing of ischemic colonic anastomoses (experimental study)

Copy For Citation

Adas G., Percem A., Adas M., Kemik O., Arikan S., Ustek D., ...More

INTERNATIONAL JOURNAL OF SURGERY, vol.9, no.6, pp.467-471, 2011 (SCI-Expanded)

Publication Type: Article / Article
Volume: 9 Issue: 6
Publication Date: 2011
Doi Number: 10.1016/j.ijsu.2011.05.002
Journal Name: INTERNATIONAL JOURNAL OF SURGERY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.467-471
Keywords: Ischemic colon anastomosis, Growth factors, Wound healing, COLLAGEN DEPOSITION, HEPARAN-SULFATE, GROWTH-FACTORS, ANGIOGENESIS, STRENGTH, SAFETY
Bezmialem Vakıf University Affiliated: No

Abstract

Background: Reducing ischemic damage is one of the goals of surgery. The aim of this study was to apply human VEGF-A and FGF-2 DNA-mediated gene therapy in order to identify their effects in the healing of ischemic colon anastomoses and eliminating the negative effects of ischemia.