Mucoccic-like lesion (MLL) of the breast has been firstly described as a benign lesion resembling mucinous carcinoma of the breast. Subsequently, it has also been reported to be associated with ductal hyperplasia or breast carcinoma. The risk of cancer development in the long term is unknown. Therefore, the approach to pure MLL of the breast detected during percutaneous biopsy is controversial. In this report, a mucocele-like breast lesion in a 47-year-old woman was first noticed during a core biopsy and later detected to be associated with ductal carcinoma in-situ focuses in excisional biopsy material is presented. The aim of this paper was to provide an overview of this rare and controversial lesion and its variabilities with regard of the presented case.