Deciphering the role of autophagy in treatment of resistance mechanisms in glioblastoma


KHAN I. , Baig M. H. , Mahfooz S., Rahim M., KARAÇAM B. , ELBASAN E. B. , ...Daha Fazla

International Journal of Molecular Sciences, cilt.22, sa.3, ss.1-26, 2021 (Diğer Kurumların Hakemli Dergileri) identifier identifier

  • Cilt numarası: 22 Konu: 3
  • Basım Tarihi: 2021
  • Doi Numarası: 10.3390/ijms22031318
  • Dergi Adı: International Journal of Molecular Sciences
  • Sayfa Sayıları: ss.1-26

Özet

© 2021 by the authors. Licensee MDPI, Basel, Switzerland.Autophagy is a process essential for cellular energy consumption, survival, and defense mechanisms. The role of autophagy in several types of human cancers has been explicitly explained; however, the underlying molecular mechanism of autophagy in glioblastoma remains ambiguous. Autophagy is thought to be a “double-edged sword”, and its effect on tumorigenesis varies with cell type. On the other hand, autophagy may play a significant role in the resistance mechanisms against various therapies. Therefore, it is of the utmost importance to gain insight into the molecular mechanisms deriving the autophagy-mediated therapeutic resistance and designing improved treatment strategies for glioblastoma. In this review, we discuss autophagy mechanisms, specifically its pro-survival and growth-suppressing mechanisms in glioblastomas. In addition, we try to shed some light on the autophagy-mediated activation of the cellular mechanisms supporting radioresistance and chemoresistance in glioblastoma. This review also highlights autophagy’s involvement in glioma stem cell behavior, underlining its role as a potential molecular target for therapeutic interventions.