Protective effect of ferulic acid on cisplatin induced nephrotoxicity in rats

Bami E., Ozakpinar O. B., Ozdemir-Kumral Z. N., Koroglu K., ERCAN F., CIRAKLI Z., ...More

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, vol.54, pp.105-111, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 54
  • Publication Date: 2017
  • Doi Number: 10.1016/j.etap.2017.06.026
  • Journal Name: ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.105-111
  • Keywords: Kidney, Cisplatin, Ferulic acid, Curctunin, INHIBITING RENAL INFLAMMATION, OXIDATIVE STRESS, CURCUMIN, KIDNEY, INJURY, MECHANISMS, APOPTOSIS, DAMAGE, BIOMARKER
  • Bezmialem Vakıf University Affiliated: No

Abstract

This study aims to determine the potential protective effects of ferulic acid against cisplatin-induced nephrotoxicity and to compare its effect with curcumin, a well-known protective agent against cisplatin- induced toxicity in rats. Administration of cisplatin resulted in high BUN (Blood Urea Nitrogen), creatinine, MDA (Malondialdehyde), MPO (Myeloperoxidase), TOS (Total Oxidative Status), PtNT (Protein Nitrotyrosine) levels (p < 0.05). Histological observations showed abnormal morphology of kidney; in addition with appearance of TUNEL positive cells indicating apoptosis in cisplatin administered group. HO-1 (Heme Oxygenase-1) levels measured by RT-PCR (Real Time Polymerase Chain Reaction), and TAS (Total Antioxidative Status) revealed antioxidant depletion due to cisplatin toxicity in animals (p < 0.05). All parameters showed improvement in groups treated with ferulic acid (p < 0.05). Ferulic acid treatment was found significant in preventing oxidative stress, increasing antioxidative status and regaining histological parameters to normal, indicating nephroprotective and antioxidant effects of this phenolic compound.