Effects of the Chemokine Receptor 5 (CCR5)-Delta32 Mutation on Hepatitis C Virus-Specific Immune Responses and Liver Tissue Pathology in HCV Infected Patients


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YILMAZ A., ALAGÖZLÜ H., ÖZDEMİR Ö., Arici S.

HEPATITIS MONTHLY, cilt.14, 2014 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 14 Konu: 7
  • Basım Tarihi: 2014
  • Doi Numarası: 10.5812/hepatmon.11283
  • Dergi Adı: HEPATITIS MONTHLY

Özet

Background: The specific antiviral T cells provide CC chemokine receptor 5 (CCR5) for the immune response during the hepatitis C virus (HCV) infection. Heterogenous and/or homozygous 32 base pair deletion in CCR5 gene (CCR5 432 bpdel) leads to reduced protein expression.