Circulating levels of cytokines are increased in restless legs syndrome

Uslu F., Demir E., Güler E. M., Koçyiğit A.

SLEEP AND BREATHING, vol.25, no.3, pp.1581-1585, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 25 Issue: 3
  • Publication Date: 2021
  • Doi Number: 10.1007/s11325-020-02218-7
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, PASCAL, EMBASE, MEDLINE
  • Page Numbers: pp.1581-1585
  • Keywords: Restless legs syndrome, Interleukin-6, Interleukin-1 beta, TNF-alpha, DISEASE, INTERLEUKIN-6, SLEEP, INFLAMMATION, ASSOCIATION
  • Bezmialem Vakıf University Affiliated: Yes


Background Restless legs syndrome [RLS] is known as a disease of iron and dopaminergic dysregulation but inflammatory processes might also have a role in the pathogenesis. In this study, we compared the circulating levels of hsCRP, IL-1 beta, IL-6, and TNF-alpha in patients with primary restless legs syndrome [RLS] and healthy control subjects.