Background. Although diseases such as diabetes,
hypertension, obstructive sleep apnea and hyperlipidemia are
clearly documented as obesity associated diseases, it is not wellknown whether obesity causes renal pathologies. The aim of the
present study was to evaluate the effect of weight loss following
laparoscopic sleeve gastrectomy on clinical, renal parameters
and urinary Neutrophil gelatinase-associated lipocalin (NGAL)
levels in diabetic and non-diabetic obese patients.
Methods. Nineteen morbidly obese patients (10
diabetic and 9 non diabetic) who underwent laparoscopic
sleeve gastrectomy were evaluated clinically (anthropometric
measurements) and biochemically before surgery and at 6
months from surgery.
Results. Significant decreases in weight, BMI, FPG,
PPG and HbA1c levels were observed in the diabetic group
when the baseline and 6th month parameters of the patients were
compared. There was also a significant decrease in SBP and
DBP. At 6th month following laparoscopic sleeve gastrectomy,
renal parameters such as creatinine, mAlb/creatinine, NGAL/
creatinine did not differ in the diabetic group. In the nondiabetic
group, serum creatinine levels were significantly decreased, but
other renal parameters such as mAlb/creatinine and NGAL/
creatinine were not significantly different.
Conclusions. Our findings revealed significant
decreases in weight, body mass index and glycemic parameters
after sleeve gastrectomy in diabetic and non-diabetic patients,
while no significant alteration was noted in renal functions,
urinary NGAL and microalbumin levels.
Key words: sleeve gastrectomy, obesity, urinary
NGAL, kidney, weight loss, T2DM.