Chemical Constituents of Two Endemic Sideritis Species from Turkey with Antioxidant Activity

Carikci S., Kilic T., Azizoglu A., Topcu G.

RECORDS OF NATURAL PRODUCTS, vol.6, no.2, pp.101-109, 2012 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 6 Issue: 2
  • Publication Date: 2012
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.101-109
  • Keywords: Lamiaceae, Sideritis niveotomentosa, Sideritis brevidens, diterpenoids, kaurane, antioxidant potential, BIOLOGICAL-ACTIVITY, POLYPHENOL CONTENTS, ENT-KAURANE, DITERPENES, LAMIACEAE, EXTRACT, NMR, L.
  • Bezmialem Vakıf University Affiliated: Yes


In this study, two Sideritis species, endemic to Turkey, S. niveotomentosa Huber - Morathii, S. brevidens P. H. Davis have been studied for their diterpenic compounds and the antioxidant properties. Eight known diterpenoids, which have ent-kaurene skeleton, were isolated from acetone and methanol extracts of these species. The structures of the isolated diterpenes were determined by using the NMR (H-1-NMR, C-13-NMR, COSY, HMQC, and HMBC) spectroscopy. The analysis of the phenolic compounds of the extracts was performed by high performance liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS). Also the antioxidant capacity of the extracts was investigated namely by two methods; free radical scavenging and beta-carotene bleaching activities.