Angiotensin-Converting Enzyme Inhibitor Enalapril Reduces Formation of Hypertrophic Scars in a Rabbit Ear Wounding Model

UZUN H., Bitik O., Hekimoglu R., Atilla P., Kayikcioglu A. U.

PLASTIC AND RECONSTRUCTIVE SURGERY, cilt.132, sa.3, 2013 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 132 Sayı: 3
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1097/prs.0b013e31829acf0a
  • Dergi Adı: PLASTIC AND RECONSTRUCTIVE SURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Bezmiâlem Vakıf Üniversitesi Adresli: Hayır

Özet

Background: Angiotensin-converting enzyme inhibitors are widely used in medicine because of their antihypertensive and antifibrogenic effects. Angiotensin-converting enzyme activates angiotensin I to angiotensin II, which plays an important regulatory role in wound healing and collagen production. The authors investigated whether systemic administration of angiotensin-converting enzyme inhibitors has any effect on formation of hypertrophic scars using the rabbit ear wound model.