Angiotensin-Converting Enzyme Inhibitor Enalapril Reduces Formation of Hypertrophic Scars in a Rabbit Ear Wounding Model

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UZUN H., Bitik O., Hekimoglu R., Atilla P., Kayikcioglu A. U.

PLASTIC AND RECONSTRUCTIVE SURGERY, vol.132, no.3, 2013 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 132 Issue: 3
• Publication Date: 2013
• Doi Number: 10.1097/prs.0b013e31829acf0a
• Journal Name: PLASTIC AND RECONSTRUCTIVE SURGERY
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Bezmialem Vakıf University Affiliated: No

Abstract

Background: Angiotensin-converting enzyme inhibitors are widely used in medicine because of their antihypertensive and antifibrogenic effects. Angiotensin-converting enzyme activates angiotensin I to angiotensin II, which plays an important regulatory role in wound healing and collagen production. The authors investigated whether systemic administration of angiotensin-converting enzyme inhibitors has any effect on formation of hypertrophic scars using the rabbit ear wound model.