Angiotensin-Converting Enzyme Inhibitor Enalapril Reduces Formation of Hypertrophic Scars in a Rabbit Ear Wounding Model


UZUN H., Bitik O., Hekimoglu R. , Atilla P., Kayikcioglu A. U.

PLASTIC AND RECONSTRUCTIVE SURGERY, vol.132, no.3, 2013 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 132 Issue: 3
  • Publication Date: 2013
  • Doi Number: 10.1097/prs.0b013e31829acf0a
  • Title of Journal : PLASTIC AND RECONSTRUCTIVE SURGERY

Abstract

Background: Angiotensin-converting enzyme inhibitors are widely used in medicine because of their antihypertensive and antifibrogenic effects. Angiotensin-converting enzyme activates angiotensin I to angiotensin II, which plays an important regulatory role in wound healing and collagen production. The authors investigated whether systemic administration of angiotensin-converting enzyme inhibitors has any effect on formation of hypertrophic scars using the rabbit ear wound model.