Angiotensin-Converting Enzyme Inhibitor Enalapril Reduces Formation of Hypertrophic Scars in a Rabbit Ear Wounding Model

UZUN H., Bitik O., Hekimoglu R., Atilla P., Kayikcioglu A. U.

PLASTIC AND RECONSTRUCTIVE SURGERY, vol.132, no.3, 2013 (SCI-Expanded) identifier identifier identifier


Background: Angiotensin-converting enzyme inhibitors are widely used in medicine because of their antihypertensive and antifibrogenic effects. Angiotensin-converting enzyme activates angiotensin I to angiotensin II, which plays an important regulatory role in wound healing and collagen production. The authors investigated whether systemic administration of angiotensin-converting enzyme inhibitors has any effect on formation of hypertrophic scars using the rabbit ear wound model.