Angiotensin-Converting Enzyme Inhibitor Enalapril Reduces Formation of Hypertrophic Scars in a Rabbit Ear Wounding Model


UZUN H., Bitik O., Hekimoglu R. , Atilla P., Kayikcioglu A. U.

PLASTIC AND RECONSTRUCTIVE SURGERY, cilt.132, 2013 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 132 Konu: 3
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1097/prs.0b013e31829acf0a
  • Dergi Adı: PLASTIC AND RECONSTRUCTIVE SURGERY

Özet

Background: Angiotensin-converting enzyme inhibitors are widely used in medicine because of their antihypertensive and antifibrogenic effects. Angiotensin-converting enzyme activates angiotensin I to angiotensin II, which plays an important regulatory role in wound healing and collagen production. The authors investigated whether systemic administration of angiotensin-converting enzyme inhibitors has any effect on formation of hypertrophic scars using the rabbit ear wound model.