Osteocalcin, Cortisol Levels, and Bone Mineral Density in Prepubertal Children with Asthma Treated with Long-Term Fluticasone Propionate


Ozkaya E. , NURSOY M. A. , Uzuner S. , Erenberk U. , Cakir E.

HORMONE RESEARCH IN PAEDIATRICS, cilt.77, ss.351-357, 2012

  • Cilt numarası: 77 Konu: 6
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1159/000338785
  • Dergi Adı: HORMONE RESEARCH IN PAEDIATRICS
  • Sayfa Sayısı: ss.351-357

Özet

Aims: The objective of this study is to determine the effects of the long-term treatment with inhaled fluticasone propionate on osteocalcin, cortisol levels, and bone mineral status in children with asthma. Methods: This cross-sectional study examined 230 prepubertal children with asthma (aged 6-11) who had intermittently used inhaled fluticasone propionate for at least 5 years at a mean daily dose of 200 mu g (range: 200-350 mu g). Serum osteocalcin, cortisol, and bone mineral density (BMD) of the lumbar spine were obtained from each participant. The control group consisted of gender-and age-matched children (n = 170) who were newly diagnosed with asthma and who were not being treated with corticosteroid. Results: The average age (+/- SEM) was 8.9 +/- 0.7 years, their mean (+/- SEM) daily steroid dose was 180.3 +/- 55.0 mu g, with 236.5 +/- 17.2 g total steroid use during treatment. Between the study and the control groups, no significant differences were observed in cortisol, osteocalcin levels, and BMD (p > 0.05). Conclusion: Long-term treatment with inhaled fluticasone propionate (100 mu g twice daily) revealed no negative effects on serum osteocalcin, cortisol levels, and BMD in children with asthma. Copyright (C) 2012 S. Karger AG, Basel