Role of Probiotics in the Management of COVID-19: A Computational Perspective

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Nguyen Q. V., Chong L. C., Hor Y., Lew L., Rather I. A., Choi S.

NUTRIENTS, vol.14, no.2, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 14 Issue: 2
  • Publication Date: 2022
  • Doi Number: 10.3390/nu14020274
  • Journal Name: NUTRIENTS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Agricultural & Environmental Science Database, BIOSIS, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database, Directory of Open Access Journals
  • Keywords: probiotics, SARS-CoV-2, COVID-19, gut-lung axis, microbiome, computational approach, molecular docking, INFLUENZA-VIRUS INFECTION, RESPIRATORY SYNCYTIAL VIRUS, LACTOBACILLUS-RHAMNOSUS GG, GUT MICROBIOTA, YOUNG-CHILDREN, PROTECTS MICE, SOFTWARE NEWS, WEB SERVER, ROTAVIRUS, DOCKING
  • Bezmialem Vakıf University Affiliated: Yes

Abstract

Coronavirus disease 2019 (COVID-19) was declared a pandemic at the beginning of 2020, causing millions of deaths worldwide. Millions of vaccine doses have been administered worldwide; however, outbreaks continue. Probiotics are known to restore a stable gut microbiota by regulating innate and adaptive immunity within the gut, demonstrating the possibility that they may be used to combat COVID-19 because of several pieces of evidence suggesting that COVID-19 has an adverse impact on gut microbiota dysbiosis. Thus, probiotics and their metabolites with known antiviral properties may be used as an adjunctive treatment to combat COVID-19. Several clinical trials have revealed the efficacy of probiotics and their metabolites in treating patients with SARS-CoV-2. However, its molecular mechanism has not been unraveled. The availability of abundant data resources and computational methods has significantly changed research finding molecular insights between probiotics and COVID-19. This review highlights computational approaches involving microbiome-based approaches and ensemble-driven docking approaches, as well as a case study proving the effects of probiotic metabolites on SARS-CoV-2.