Triterpene saponins from Eryngium campestre

Kartal M., MITAINE-OFFER A., PAULULAT T., ABU-ASAKER M., WAGNER H., MIRJOLET J., ...More

JOURNAL OF NATURAL PRODUCTS, vol.69, no.7, pp.1105-1108, 2006 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 69 Issue: 7
  • Publication Date: 2006
  • Doi Number: 10.1021/np060101w
  • Journal Name: JOURNAL OF NATURAL PRODUCTS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1105-1108
  • Bezmialem Vakıf University Affiliated: No

Abstract

Five new triterpene saponins, 3-O-alpha-L-rhamnopyranosyl-(1 -> 2)-beta-D-glucuronopyranosyl-22-O-beta,beta-dimethylacryloyl-A1-barrigenol (1), 3-O-alpha-L-rhamnopyranosyl-(1 -> 2)-beta-D-glucuronopyranosyl-22-O-angeloyl-R1-barrigenol (2), 3-O-alpha-L-rhamnopyranosyl-(1 -> 2)-beta-D-glucuronopyranosyl-21-O-acetyl-22-O-angeloyl-R1-barrigenol (3), 3-O-alpha-L-rhamnopyranosyl-(1 -> 2)-beta-D-glucuronopyranosyl-21-O-acetyl-22-O-beta,beta-dimethylacryloyl-R1-barrigenol (4), and 3-O-alpha-L-rhamnopyranosyl-( 1 -> 2)-beta-D-glucuronopyranosyl-22-O-angeloyl-28-O-acetyl-R1-barrigenol (5), were isolated from the roots of Eryngium campestre. Their structures were established mainly by 2D NMR techniques and mass spectrometry. Compounds 1-4 and 3-O-beta-D-glucopyranosyl-(1 -> 2)-[alpha-L-rhamnopyranosyl-(1 -> 4)]-beta-D-glucuronopyranosyl-22-O-beta,beta-dimethylacryloyl-A1-barrigenol, previously isolated from the same plant, showed a weak cytotoxicity when tested against HCT 116 and HT 29 human colon cancer cells.