Cytokine Expression Profile of Dengue Patients at Different Phases of Illness

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Rathakrishnan A., Wang S. M. , Hu Y., KHAN M. A. , Ponnampalavanar S., Lum L. C. S. , ...More

PLOS ONE, vol.7, no.12, 2012 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 7 Issue: 12
  • Publication Date: 2012
  • Doi Number: 10.1371/journal.pone.0052215
  • Title of Journal : PLOS ONE


Background: Dengue is an important medical problem, with symptoms ranging from mild dengue fever to severe forms of the disease, where vascular leakage leads to hypovolemic shock. Cytokines have been implicated to play a role in the progression of severe dengue disease; however, their profile in dengue patients and the synergy that leads to continued plasma leakage is not clearly understood. Herein, we investigated the cytokine kinetics and profiles of dengue patients at different phases of illness to further understand the role of cytokines in dengue disease.