Cytotoxic activity of some anatolian Salvia extracts and isolated abietane diterpenoids


Topcu G. , Turkmen Z., SCHILLING J. K. , KINGSTON D. G. I. , PEZZUTO J. M. , Ulubelen A.

PHARMACEUTICAL BIOLOGY, cilt.46, ss.180-184, 2008 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 46 Konu: 3
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1080/13880200701735411
  • Dergi Adı: PHARMACEUTICAL BIOLOGY
  • Sayfa Sayısı: ss.180-184

Özet

Salvia hypargeia Fisch. et Mey. (Larmiaceae) root extract, among 16 Salvia extracts, showed the high est activity against the human ovarian cancer cell line. Bioactivity-guided fractionation of this plant extract has yielded four abietane-type diterpenes [5,6-didehydro-7-hydroxytaxodone (1), 14-deoxycoleon U (=6-hydroxysalvinolone) (2), demethylcryptojaponol (3), and salvicanaric acid (4)] two triterpenes (lupeol and lupeol-3-acetate), and a fatty acid mixture consisting mainly of palmitic acid (51.6%) and palmitoleic acid (6.4%). Compounds 2 and 3 were found to be active against A2780 human ovarian cancer cell line with IC50 values of 3.9 an 1.2 mu g/mL, respectively, and the fatty acid composition was the most active part of the extract (IC50 = 0.6 mu g/mL).