Neurogenic heterotopic ossification in Guillain-Barre syndrome: a rare case report

Nalbantoglu M., Tuncer O. G., Acik M. E., Matur Z., Altunrende B., Ozgonenel E., ...More

JOURNAL OF MUSCULOSKELETAL & NEURONAL INTERACTIONS, vol.20, no.1, pp.160-164, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 20 Issue: 1
  • Publication Date: 2020
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, EMBASE, MEDLINE
  • Page Numbers: pp.160-164
  • Keywords: Neurogenic Heterotopic Ossification, Guillain Barre Syndrome, Prolonged Immobilisation, Mechanical Ventilation, GBS, TRAUMATIC BRAIN-INJURY, GENE-EXPRESSION
  • Bezmialem Vakıf University Affiliated: No


Neurogenic heterotopic ossification (NHO) is an abnormal development of bone in extra-skeletal tissues, related to neurological disease. NHO is frequently seen after traumatic brain injury or spinal cord injury. NHO may also occur as a rare complication of Guillain Barre Syndrome (GBS). Here, we present a 39 year old man with an acute onset of GBS who developed NHO around both hips two months after the disease onset. Our patient had a history of mechanical ventilation, incomplete tetraplegia and prolonged immobilisation. The pathogenesis of NHO is unclear. Various risk factors have been associated with the development of NHO; prolonged coma, long-term sedation, spasticity, degree of paralysis. NHO is a rare complication of GBS and physicians should be aware that it can develop especially in patients with severe paralysis and in need of mechanical ventilation. Pain and restriction of movements, especially in the hips, should bring NHO to the mind.