Malignant neural sheath tumors are categorized as malignant peripheral nerve sheath tumors (MPNST), malignant granular cell tumors and ectomesenchymoma. Tumors other than MPNSTs are rarely seen. MPNSTs comprise a small portion of all soft tissue sarcomas, which accounts to approximately 5%. They are typically seen between the ages 20-50 and women are affected more frequently than men. Lower extremities are the most common sites. Most MPNSTs occur in conjuction with large peripheral nerves such as sciatic nerve. Neuropathic symptoms can be also observed in patients with growing lesions. Magnetic resonance imaging (MRI) is the preferred imaging modality. Malignant vascular tumors originate from vascular endothelium. Peak age of incidence appears to be seventh decade, although they might be seen in all ages. Generally the etiology is unclear, but it is known that some cases are associated with radiation. The lesions are often localized to the lower extremities. The World Health Organization (WHO) has categorized malignant vascular tumors into different subtypes, with angiosarcoma ranking as the most prominent. These tumors are very aggressive and have a high mortality rate.