Comparison of the protective effects of various antiulcer agents alone or in combination on indomethacin-induced gastric ulcers in rats


Izzettin F. V. , SANCAR M., OKUYAN B., Apikoglu-Rabus S., Cevikbas U.

EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY, vol.64, no.4, pp.339-343, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 64 Issue: 4
  • Publication Date: 2012
  • Doi Number: 10.1016/j.etp.2010.09.007
  • Journal Name: EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.339-343
  • Keywords: Indomethacin-induced gastric ulcer, Omeprazole, Misoprostol, Ranitidine, Bismuth, Rat, NONSTEROIDAL ANTIINFLAMMATORY DRUGS, OMEPRAZOLE, MISOPROSTOL, PREVENTION, CIMETIDINE, SUCRALFATE, ASPIRIN, THERAPY
  • Bezmialem Vakıf University Affiliated: No

Abstract

The aim of this study which was structured with the objective of determination of the optimum protective therapy against the long term NSAID therapy-induced ulcers was to compare the gastro-protective effects of various antiulcer drugs (ranitidine, omeprazole, bismuth and misoprostol)alone or in combination with each other in different doses on indomethacin-induced gastric ulcers in rats.