The Relationships Between Oxidative Stress, Inflammation, Trace Elements And Cardiometabolic Parameters In The Etiopathogenesis Of Essential Hypertension.

Cinemre F. B., Bahtiyar N., Özman Z., Ağaç M. T., Kahyaoğlu B., Aydemir B., ...More

Union of Thrace Universities 2nd International Health Sciences Congress, Tekirdağ, Turkey, 15 - 17 November 2018, pp.6

  • Publication Type: Conference Paper / Summary Text
  • City: Tekirdağ
  • Country: Turkey
  • Page Numbers: pp.6
  • Bezmialem Vakıf University Affiliated: Yes

Abstract

Introduction:Inflammation and oxidative stress are known to be associated with  chronic diseases, such as essential hypertension.Some trace elements also play a role in the oxidant/antioxidant system and inflammation processes. In this study we aim to investigate a relationship between selenium,zinc,copper,superoxide dismutase, TNF-α,IL-6,IL-4,IL-10,IL-1β and some metabolic parameters playing role essential hypertension.

Materials/Methods:116 essential hypertensive patients and 40 healthy controls were studied.Serum superoxide dismutase,TNF-α,IL-4,IL-10,IL-6 and IL-1β were measured by ELISA assay.Selenium,zinc and copper levels were measured by inductively coupled plasma optical emission spectrometry(ICP-OES).Serum biochemical parameters of study subjects were analyzed by auto-analyzers.

Results: Serum selenium levels showed a positive correlation with waist circumference and copper(r=0.172, p=0.05;r=0.229,P<0.014,respectively).Additionally, serum zinc levels showed a positive correlation with glucose and copper levels(r=0.221,P<0.014;r=0.173,P<0.05,respectively).Moreover, superoxide dismutase activities found a positive correlation with body mass index(BMI) and IL-8(r=0.562,P<0.012;r=0.969,P<0.007,respectively).IL-4 levels found a positive correlation with glucose, systolic and diastolic pressure values(r=0.340,P<0.026;r=0.363,P<0.030,r=0.290,P<0.050,respectively).Also,IL-10 levels showed a positive correlation with systolic and diastolic pressure values(r=0.299,P<0.046 and r=0.287, P<0.050, respectively).However, there was a negative correlation between IL-1β and glucose levels(r=-0.302,P<0.05). There was also,a negative correlation between TNF-α and systolic, and diastolic pressure(r=-0.269,P<0.05;r=-0.307,P<0.05, respectively).Superoxide dismutase activities found a negative correlation with TNF-α(r=-0.957, P<0.043).

Conclusion: We concluded that the circulatory changes of trace elements, oxidant/antioxidant status and inflammatory cytokines in hypertensive patients may play a role in the occurrence of various complications by affecting cardio-metabolic parameters.

Keywords: essential hypertension,oxidative stress,trace elements