A 17-Year-Old Female with Systemic Lupus Presents with Complex Movement Disorder: Possible Relationship with Antiribosomal P Antibodies


Ozcan M. E. , Altinoz M. A. , Karadeli H. H. , ASİL T. , Kocer A.

CASE REPORTS IN NEUROLOGICAL MEDICINE, 2013 (Journal Indexed in ESCI) identifier

  • Publication Type: Article / Article
  • Volume:
  • Publication Date: 2013
  • Doi Number: 10.1155/2013/590729
  • Title of Journal : CASE REPORTS IN NEUROLOGICAL MEDICINE

Abstract

Complex movement disorder is a relatively rare presentation of neurolupus. Antiphospholipid antibodies are associated with movement disorders likely via aberrant neuronal stimulation. Antiribosomal P antibodies have been previously associated with neuropsychiatric disorders but their correlation with movement disorder was not previously established. Our case report involves a 17-year-old Caucasian female patient positive for only antiribosomal P antibody and lupus anticoagulant who presented with a sudden onset of complex movement disorder. After complete cessation of physical signs with olanzapine, anticardiolipin and anti-beta 2 glycoprotein I antibodies became positive which indicates a likely discordance between movement disorder and antiphospholipid antibodies. This also indicates a potential causal role of antiribosomal P antibodies in inducing movement disorder.