May TLR4 Asp299Gly and IL17 His161Arg polymorphism be associated with progression of primary measles infection to subacute sclerosing panencephalitis?


Karakas-Celik S., Piskin I. E. , Keni M. F. , Calik M., Iscan A. , Dursun A.

GENE, cilt.547, ss.186-190, 2014 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 547 Konu: 2
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1016/j.gene.2014.03.056
  • Dergi Adı: GENE
  • Sayfa Sayıları: ss.186-190

Özet

SSPE is a progressive neurological disorder of children. Only some of the children who are infected with measles virus develop SSPE, which supports individual variation. TLR-2 and TLR-4 play an important role in innate immunity by recognizing envelope proteins of MV. Another important cytokine that plays an important role in orchestrating innate immune function is IL-17. The purpose of our study is to elucidate whether the TLR2, TLR4, IL17F and IL17A gene polymorphisms are susceptibility genes for the development of SSPE.