This study aimed to evaluate the microtensile bond strength and amount of microleakage with self-etch adhesives. For the bond strength study, 50 human third molars were randomly assigned to five groups according to the adhesive system used. In each group, half of the specimens were subjected to the microtensile test immediately after the bonding procedures and tooth sectioning, while the remaining half were subjected to the test after storage in distilled water for 3 months. For the microleakage study, following the preparation and restoration of class V cavities, 70 human molars were divided into two groups for the five adhesives; the specimens in one group were stored in distilled water for 24 h and those in the other group were stored for 3 months. In both groups, the teeth were sectioned and evaluated for dye penetration after the storage time. After 24 h, the microtensile bond strengths in descending order were as follows: Clearfil SE Bond > G Aenial Bond > Optibond All-in-One (AiO) > Adper Prompt L Pop (hereafter L Pop) > Futurabond M. After 3 months, the mu TBS of all five bonding agents was decreased, although the decrease was significant only for L Pop, which showed the highest scores for leakage around the enamel margins, whereas Futurabond M showed the highest scores for leakage around the gingival margins. After 3 months, the microleakages scores significantly increased for G Aenial Bond, Futurabond M and OptibondAiO.