BETA-ADRENERGIC RESPONSIVENESS OF THE GASTROINTESTINAL-TRACT IN DIABETIC RATS


OZTURK Y., ALTAN V. M. , YILDIZOGLUARI N.

PHARMACOLOGY & TOXICOLOGY, vol.71, no.4, pp.250-253, 1992 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 71 Issue: 4
  • Publication Date: 1992
  • Doi Number: 10.1111/j.1600-0773.1992.tb00978.x
  • Title of Journal : PHARMACOLOGY & TOXICOLOGY
  • Page Numbers: pp.250-253

Abstract

Recently, decreased gastrointestinal beta-adrenergic responses in experimental diabetes have been demonstrated. Gastrointestinal responses to beta-adrenoceptor agonists are impaired in both insulin-dependent and non-insulin-dependent diabetic rat. Insulin treatment improves the impaired gastrointestinal beta-adrenergic responsiveness of diabetic rats. The improvement seen with insulin treatment on beta-adrenergic responsiveness is closely related to protein biosynthesis. The decreased beta-adrenergic responses in diabetic rat gastrointestinal tract seem to result from a decrease in the number of beta-adrenoceptors. It is most likely that the decreased gastrointestinal beta-adrenergic responsiveness is related to an impairment in the turnover of beta-adrenoceptors as a consequence of diabetes and that insulin has a beneficial effect on the impaired receptor turnover.