Antiinflammatory and Antinociceptive properties of luteolin diglucuronide and apigenin diglucuronide obtained from Perilla nankinensis

Bueyuekokuroglu M. E., Berashvili D., Gepdiremen A. A., Altinkeser M.

ASIAN JOURNAL OF CHEMISTRY, vol.20, no.3, pp.1900-1906, 2008 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 20 Issue: 3
  • Publication Date: 2008
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1900-1906
  • Bezmialem Vakıf University Affiliated: No


This study aimed to examine possible anti inflammatory and antinociceptive effects of luteolin diglucuronide (LT). apigenin diglucuronide (AP) and semi-pure luteolin diglucuronide (S-LT) obtained from Perilla nankinensis in rats and mice. Anti inflammatory effects of LT. AP and S-LT were investigated with the carrageenaan-induced rat paw edema tests. It was found that pretreatment with LT, AP and S-LT obtained from Perilla nankinensis reduced inflammagen -induced paw edema in rats. Again. pretreatment with LT significantly diminished the nociceptive response in mice. LT and AP present in the leaves of Perilla nankinensis may partly account for the antiinflammatory and antinociceptive properties of Perilla nankinensis.