Rare diagnosis of an Epstein‑Barr virus‑positive extracavitary/solid variant of primary effusion lymphoma by duodenal endoscopic biopsy in a human immunodeficiency virus‑seronegative and immunocompetent patient: A case report

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Güler B., Çetin G.

INDIAN JOURNAL OF PATHOLOGY AND MICROBIOLOGY, no.2, pp.1-4, 2023 (SCI-Expanded)

  • Publication Type: Article / Case Report
  • Publication Date: 2023
  • Doi Number: 10.4103/ijpm.ijpm_955_22
  • Journal Name: INDIAN JOURNAL OF PATHOLOGY AND MICROBIOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database, Directory of Open Access Journals
  • Page Numbers: pp.1-4
  • Bezmialem Vakıf University Affiliated: Yes

Abstract

Primary effusion lymphoma and its tissue‑based subtype extracavitary/solid

variant was first described in human immunodeficiency virus (HIV)‑seropositive

patients. We report the case of a 50‑year‑old HIV‑seronegative male patient

who presented with icterus and cholestasis. Computed tomography revealed

a 80 × 56 mm abdominal mass. Fine‑needle aspiration biopsy was performed

from the celiac lymph nodes and pancreatic head, under endoscopic

ultrasonography guidance. A duodenal endoscopic biopsy was taken from the

infiltration area, and a core biopsy was performed for the portal hilar mass.

All biopsies showed similar cytohistopathological features. LCA‑positive

lymphoid neoplasia had a plasmacytoid/anaplastic morphology and null cell

phenotype. HHV‑8 and Epstein‑Barr virus‑encoded small RNAs (EBER)

were diffuse positive. The patient, who did not have an effusion, was

diagnosed with an extracavitary/solid variant of primary effusion lymphoma.

Virus‑associated lymphoproliferative disorders should be considered in the

differential diagnosis of patients without a history of immunosuppression or

HIV infection.