INDIAN JOURNAL OF PATHOLOGY AND MICROBIOLOGY, no.2, pp.1-4, 2023 (SCI-Expanded)
Primary effusion lymphoma and its tissue‑based subtype extracavitary/solid
variant was first described in human immunodeficiency virus (HIV)‑seropositive
patients. We report the case of a 50‑year‑old HIV‑seronegative male patient
who presented with icterus and cholestasis. Computed tomography revealed
a 80 × 56 mm abdominal mass. Fine‑needle aspiration biopsy was performed
from the celiac lymph nodes and pancreatic head, under endoscopic
ultrasonography guidance. A duodenal endoscopic biopsy was taken from the
infiltration area, and a core biopsy was performed for the portal hilar mass.
All biopsies showed similar cytohistopathological features. LCA‑positive
lymphoid neoplasia had a plasmacytoid/anaplastic morphology and null cell
phenotype. HHV‑8 and Epstein‑Barr virus‑encoded small RNAs (EBER)
were diffuse positive. The patient, who did not have an effusion, was
diagnosed with an extracavitary/solid variant of primary effusion lymphoma.
Virus‑associated lymphoproliferative disorders should be considered in the
differential diagnosis of patients without a history of immunosuppression or