Inhibition of Amyloid β Aggregation Using Optimized Nano Encapsulated Formulations of Plant Extracts with High Metal Chelator Activities.

Kazdal F., Bahadori F., Celik B., Ertas A., Topcu G.

Current pharmaceutical biotechnology, vol.21, pp.681-701, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 21
  • Publication Date: 2020
  • Doi Number: 10.2174/1389201021666191210125851
  • Journal Name: Current pharmaceutical biotechnology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Agricultural & Environmental Science Database, BIOSIS, Biotechnology Research Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE
  • Page Numbers: pp.681-701
  • Keywords: Alzheimer, apo E4, metal chelator, nano-drug delivery, polyphenol, amyloid beta, ALZHEIMERS-DISEASE, ESSENTIAL OIL, FATTY-ACID, BIOLOGICAL-ACTIVITIES, A-BETA, GC-MS, ANTIOXIDANT, ANTICHOLINESTERASE, PROTEIN, PROFILE
  • Bezmialem Vakıf University Affiliated: Yes

Abstract

Background: The role of Fe+2, Cu+2 and Zn+2 in facilitating aggregation of Amyloid beta (A beta) and consequently, the progression of Alzheimer's disease (AD) is well established.