Introduction: Primary lymphoma of the bone (PLB) is a rare clinicopathological disease. PLB accounts for approximately 3% of all malignant tumors. It frequently affects the femur and pelvis, and the spine is affected only in 1.7% of all cases. Because it is a rare disease, the optimal treatment strategy has not yet been established. Case presentation: We present a case of a 36-year-old male who had complaints of back pain, leg pain and fatigue that did not affect his daily tasks. The positron emission tomography (PET) also showed multifocal lesions of bones. An excisional biopsy of osteolytic lesions in the left scapula revealed diffuse large B-cell Non-Hodgkin Lymphoma. Chemotherapy was administered and complete response was observed. Conclusion: Multifocal PLB is an exceptional situation. The diagnosis is challenging because of the low incidence and unspecific radiological features. Studies should be carried out to identify the optimal treatment in the future. Here, we want to emphasize the complete response with chemotherapy of a multicentric involvement primary bone lymphoma.