Protective effect of trimetazidine on amikacin-induced ototoxicity in rats.

AKSOY F., Dogan R., Ozturan O., EREN S. B., VEYSELLER B., PEKTAS A., ...Daha Fazla

International journal of pediatric otorhinolaryngology, cilt.78, sa.4, ss.663-9, 2014 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 78 Sayı: 4
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1016/j.ijporl.2014.01.031
  • Dergi Adı: International journal of pediatric otorhinolaryngology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.663-9
  • Anahtar Kelimeler: ABR, Amikacin, DPOAE, Oxidative status, Trimetazidine, TOTAL ANTIOXIDANT CAPACITY, INDUCED HEARING-LOSS, DOUBLE-BLIND, DAMAGE, GENTAMICIN, PREVENTION, AMINOGLYCOSIDES, REPERFUSION, ATTENUATION, RADICALS
  • Bezmiâlem Vakıf Üniversitesi Adresli: Evet

Özet

Objective: Aminoglycoside antibiotics are known to have ototoxic effects and may induce sensorineural hearing loss. This study investigated the protective effect of trimetazidine, which has antioxidant and cytoprotective properties, against amikacin ototoxicity.