Protective effect of trimetazidine on amikacin-induced ototoxicity in rats.

AKSOY F., Dogan R., Ozturan O., EREN S. B. , VEYSELLER B., PEKTAS A., ...More

International journal of pediatric otorhinolaryngology, vol.78, no.4, pp.663-9, 2014 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 78 Issue: 4
  • Publication Date: 2014
  • Doi Number: 10.1016/j.ijporl.2014.01.031
  • Journal Name: International journal of pediatric otorhinolaryngology
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.663-9
  • Keywords: ABR, Amikacin, DPOAE, Oxidative status, Trimetazidine, TOTAL ANTIOXIDANT CAPACITY, INDUCED HEARING-LOSS, DOUBLE-BLIND, DAMAGE, GENTAMICIN, PREVENTION, AMINOGLYCOSIDES, REPERFUSION, ATTENUATION, RADICALS

Abstract

Objective: Aminoglycoside antibiotics are known to have ototoxic effects and may induce sensorineural hearing loss. This study investigated the protective effect of trimetazidine, which has antioxidant and cytoprotective properties, against amikacin ototoxicity.