Effect of 5-aminoimidazole-4-carboxamide riboside (aica-r) on isolated thoracic aorta responses in streptozotocin-diabetic rats

Senses V., Ozyazgan S., İNCE E. Z., TUNÇDEMİR M., Kaya F., ÖZTÜRK SEZGİN M., ...More

Journal of Basic and Clinical Physiology and Pharmacology, vol.12, no.3, pp.227-248, 2001 (Scopus) identifier identifier


Diabetes mellitus alters the vascular responsiveness to several vasoconstrictors and vasodilators. 5-amino-4-imidazole-carboxamide riboside (AICA-r), a nucleoside corresponding to AICA-ribotide and an intermediate of the de novo pathway of purine biosynthesis, was recently proposed as a new insulinotropic tool in non-insulin-dependent diabetes mellitus. The aim of the present study was to define whether AICA-r affects altered vascular responsiveness to vasoconstrictors and vasodilators in the thoracic aorta of neonatal streptozotocin (STZ)-diabetic rats. The results of this study indicate that a 1-month treatment with AICA-r significantly increases the body weight in diabetic rats; significantly decreases the blood glucose level of diabetic rats (from 302±47 to 135±11 mg/dL, p< 0.001); does not significantly affect the fast, slow, and total components of responses to noradrenaline in all the experimental groups; reverses the increased Emaxvalues of noradrenaline in diabetic rats to near-control values; reverses the completely abolished responses of acetylcholine (pD2 and percent relaxation) in diabetic rats to control values; and reverses the decreased pD2values of sodium nitroprussiate in diabetic rats to control values. In conclusion, AICA-r treatment in neonatal STZ-diabetic rats improved increased blood glucose levels, accelerated weight gain, reversed endothelial dysfunction, and normalized vascular responses. © 2011, by Walter de Gruyter GmbH & Co. All rights reserved.