Objective: The aim of this study is to determine invasive device-related nosocomial infection (IDRNI) rates of our hospital and to determine new strategies by reviewing infection control measures and to improve the quality of patient care and treatment. Material and Methods: Our study was carried out as an active, prospective, patient and laboratory based surveillance study by recording daily data of 1567 patients who had been monitored longer than 48 hours in Anesthesiology and Reanimation Clinic of Bakirkoy Dr. Sadi Konuk Training and Research Hospital between January 2008-January 2011. Estimations and diagnosis were done according to Center for Disease Control and prevention-CDC criteria. Results: A total of 252 invasive device-related nosocomial infections were detected in 12.981 patient days of 1567 patients during three years, between January 2008 and January 2011. Ventilator-related pneumonia rates was detected as 12.60, 16.87 and 16.21, respectively in 1000 ventilator days according to years. Central catheter-related bloodstream infection rate was found as 12.36, 9.53 and 6.44, respectively in 1000 catheter days according to years. Catheter-related urinary system infection rates were found as 5.09, 5.76 and 1.81 in 1000, respectively urinary catheter days according to years. The most common pathogen isolated from invasive device-related nosocomial infection in three years was Acinetobacter spp. (24.2%) followed by coagulase negative staphylococcus (11.4%), Pseudomonas aeruginosa (11.4%), Escherichia coli (11%) and Staphylococcus aureus (10.6%). Conclusion: IDRNI rates in our clinic are consistent with data reported from Turkey. Our main aim will be to reduce these rates by increasing effective protection methods.