Anti-Alzheimer, antidiabetic and antioxidant potential of Satureja cuneifolia and analysis of its phenolic contents by LC-MS/MS


Taslimi P., KÖKSAL E., GÖREN A. C. , Bursal E., Aras A., Kilic O., ...More

ARABIAN JOURNAL OF CHEMISTRY, vol.13, no.3, pp.4528-4537, 2020 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 13 Issue: 3
  • Publication Date: 2020
  • Doi Number: 10.1016/j.arabjc.2019.10.002
  • Title of Journal : ARABIAN JOURNAL OF CHEMISTRY
  • Page Numbers: pp.4528-4537
  • Keywords: Anti-Alzheimer, Antidiabetic, Antioxidant activity, Satureja cuneifolia, LC-MS/MS, LYOPHILIZED AQUEOUS EXTRACT, POLYPHENOL CONTENT, CRYSTAL-STRUCTURE, ANTIMICROBIAL ACTIVITIES, BIOLOGICAL EVALUATION, CARBONIC-ANHYDRASE, ALPHA-AMYLASE, PURIFICATION, DERIVATIVES, PEROXIDASE

Abstract

Many chronic diseases such as diabetes and Alzheimer's disease are related to the type and quality of foods, which are consumed. Particularly, various plant origin products are stated as beneficial against such kind of chronic diseases with secondary metabolites such as their phenolic structures. Satureja cuneifolia is a plant, which is consumed as an herbal tea in some regions of Turkey and that's why investigate of its biological activity is important. In our study, the anti-diabetic and anti-Alzheimer potentials of the methanol and water extracts of S. cuneifolia plant were measured via some enzymes inhibition experiments as in vitro. The antioxidant ability of the same extracts was measured via radical scavenging and reducing power methods. Also, the total phenolics and flavonoids of the plant were identified. Finally, the extracts were analyzed by the LC-MS/MS analysis and the phenolic content of S. cuneifolia was clarified. (C) 2019 The Author(s). Published by Elsevier B.V. on behalf of King Saud University.