The effect of propranolol on maximal electroshock seizures in mice


Akkan A. G. , Yillar D., Eskazan E., Akcasu A., Ozuner Z.

International Journal of Clinical Pharmacology Therapy and Toxicology, vol.27, no.5, pp.255-257, 1989 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 5
  • Publication Date: 1989
  • Journal Name: International Journal of Clinical Pharmacology Therapy and Toxicology
  • Journal Indexes: Science Citation Index Expanded
  • Page Numbers: pp.255-257

Abstract

The aim of this study was to determine the possible effect of propranolol, a β-adrenoceptor blocker, on maximal electroshock seizures (MES) in mice. It was found that doses of 5, 10 and 20 mg/kg propranolol caused an increase in the convulsion threshold of maximal electroshock seizures (MES) proportional to the dose and, that the mode of the anticonvulsant action of propranolol used doses in this study is related to membrane stabilization.