Antioxidant therapy impresses in oxidative stress-induced kidney cells

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Alpay M., Kismali G., Meral O., Sel T., Ozmerdivenli R., Pasin Ö.

BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY, cilt.118, sa.2, ss.89-94, 2017 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 118 Sayı: 2
  • Basım Tarihi: 2017
  • Doi Numarası: 10.4149/bll_2017_019
  • Dergi Adı: BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.89-94
  • Anahtar Kelimeler: alpha lipoic acid, apoptosis, H2O2, kidney, ROS, ALPHA-LIPOIC ACID, HYDROGEN-PEROXIDE, CANCER-CELLS, CARCINOMA, APOPTOSIS, MECHANISMS, PATHWAYS
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Bezmiâlem Vakıf Üniversitesi Adresli: Hayır

Özet

INTRODUCTION: Renal cell cancer (RCC) is not a single entity, but consists of different types of tumors derived from various parts of the nephron (epithelium or renal tubules). It is known that cancer initiation and progression is related to the balance between oxidants and antioxidants directly. Interestingly, advanced stages of cancer such as metastasis, angiogenesis are associated with cell oxidative capacity. Familiar antioxidative substances such as carotenes and vitamin C inhibit oxidation of other molecules during carcinogenesis. They can define the distinction between cancer and normal cells, destroying cancer cells while stabilizing healthy cells.