Antioxidant therapy impresses in oxidative stress-induced kidney cells

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Alpay M., Kismali G., Meral O., Sel T., Ozmerdivenli R., Pasin Ö.

BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY, vol.118, no.2, pp.89-94, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 118 Issue: 2
  • Publication Date: 2017
  • Doi Number: 10.4149/bll_2017_019
  • Journal Name: BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.89-94
  • Keywords: alpha lipoic acid, apoptosis, H2O2, kidney, ROS, ALPHA-LIPOIC ACID, HYDROGEN-PEROXIDE, CANCER-CELLS, CARCINOMA, APOPTOSIS, MECHANISMS, PATHWAYS
  • Bezmialem Vakıf University Affiliated: No

Abstract

INTRODUCTION: Renal cell cancer (RCC) is not a single entity, but consists of different types of tumors derived from various parts of the nephron (epithelium or renal tubules). It is known that cancer initiation and progression is related to the balance between oxidants and antioxidants directly. Interestingly, advanced stages of cancer such as metastasis, angiogenesis are associated with cell oxidative capacity. Familiar antioxidative substances such as carotenes and vitamin C inhibit oxidation of other molecules during carcinogenesis. They can define the distinction between cancer and normal cells, destroying cancer cells while stabilizing healthy cells.