Protective Effect of Curcumin on Cadmium-Induced Liver Apoptosis in Rats

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Bayindir N., EŞREFOĞLU M., Kumas M., Iraz M., Kesgin S., Kilic E.

BEZMIALEM SCIENCE, vol.4, no.3, pp.99-105, 2016 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 4 Issue: 3
  • Publication Date: 2016
  • Doi Number: 10.14235/bs.2016.714
  • Journal Name: BEZMIALEM SCIENCE
  • Journal Indexes: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Page Numbers: pp.99-105
  • Bezmialem Vakıf University Affiliated: Yes

Abstract

Objective: Cadmium (CD), which is used for many industrial purposes, is a toxic agent. CD accumulates in the liver; therefore, exposure to toxic doses of Cd results in hepatic damage. Studies in rats have shown that CD induces apoptosis in hepatocytes. Curcumin is a natural compound isolated from Curcuma longa. It has a powerful anti-inflammatory affect and scavenges reactive oxygen radicals. Additionally, it has been shown to have an anti-apoptotic effect in a dose-dependent manner. The aim of the present study was to evaluate the effects of therapeutic doses of curcumin on Cd-induced hepatic apoptosis as well as hepatic biochemical and inflammatory changes in Sprague-Dawley rats.