Akademik Veri Yönetim Sistemi
WORLD JOURNAL OF GASTROENTEROLOGY, cilt.30, sa.24, ss.3036-3043, 2024 (SCI-Expanded, Scopus)
Autophagy, a conserved cellular degradation process, is crucial for various
cellular processes such as immune responses, inflammation, metabolic and
oxidative stress adaptation, cell proliferation, development, and tissue repair and
remodeling. Dysregulation of autophagy is suspected in numerous diseases,
including cancer, neurodegenerative diseases, digestive disorders, metabolic
syndromes, and infectious and inflammatory diseases. If autophagy is disrupted,
for example, this can have serious consequences and lead to chronic inflammation
and tissue damage, as occurs in diseases such as Chron's disease and ulcerative
colitis. On the other hand, the influence of autophagy on the development and
progression of cancer is not clear. Autophagy can both suppress and promote the
progression and metastasis of cancer at various stages. From inflammatory bowel
diseases to gastrointestinal cancer, researchers are discovering the intricate role of
autophagy in maintaining gut health and its potential as a therapeutic target.
Researchers should carefully consider the nature and progression of diseases such
as cancer when trying to determine whether inhibiting or stimulating autophagy
is likely to be beneficial. Multidisciplinary approaches that combine cutting-edge
research with clinical expertise are key to unlocking the full therapeutic potential
of autophagy in digestive diseases