Sambulin A and B, non-glycosidic iridoids from Sambucus ebulus, exert significant in vitro anti-inflammatory activity in LPS-induced RAW 264.7 macrophages via inhibition of MAPKs's phosphorylation

Balkan, Irem; Akulke, Ayca; Bagatur, Yesim; Telci, Dilek; Goren, AHMET; Kirmizibekmez, Hasan; Yesilada, Erdem

doi:10.1016/j.jep.2017.06.002

Sambulin A and B, non-glycosidic iridoids from Sambucus ebulus, exert significant in vitro anti-inflammatory activity in LPS-induced RAW 264.7 macrophages via inhibition of MAPKs's phosphorylation

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Balkan I. A., Akulke A. Z. I., Bagatur Y., Telci D., Goren A. C., Kirmizibekmez H., ...More

JOURNAL OF ETHNOPHARMACOLOGY, vol.206, pp.347-352, 2017 (SCI-Expanded)

Publication Type: Article / Article
Volume: 206
Publication Date: 2017
Doi Number: 10.1016/j.jep.2017.06.002
Journal Name: JOURNAL OF ETHNOPHARMACOLOGY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.347-352
Bezmialem Vakıf University Affiliated: No

Abstract

Ethnopharmacological relevance: The leaves of Sambucus ebulus L. (Adoxaceae) are widely used in Turkish folk medicine particularly against inflammatory disorders. The fresh leaves after wilted over fire or the poultices prepared are directly applied externally to heal burns, edema, eczema, urticarial and abscess. Two iridoids were recently isolated (sambulin A, sambulin B) from the leaves of S. ebulus.