Sambulin A and B, non-glycosidic iridoids from Sambucus ebulus, exert significant in vitro anti-inflammatory activity in LPS-induced RAW 264.7 macrophages via inhibition of MAPKs's phosphorylation


Balkan I. A. , Akulke A. Z. I. , Bagatur Y., Telci D., Goren A. C. , Kirmizibekmez H., ...More

JOURNAL OF ETHNOPHARMACOLOGY, vol.206, pp.347-352, 2017 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 206
  • Publication Date: 2017
  • Doi Number: 10.1016/j.jep.2017.06.002
  • Title of Journal : JOURNAL OF ETHNOPHARMACOLOGY
  • Page Numbers: pp.347-352

Abstract

Ethnopharmacological relevance: The leaves of Sambucus ebulus L. (Adoxaceae) are widely used in Turkish folk medicine particularly against inflammatory disorders. The fresh leaves after wilted over fire or the poultices prepared are directly applied externally to heal burns, edema, eczema, urticarial and abscess. Two iridoids were recently isolated (sambulin A, sambulin B) from the leaves of S. ebulus.