Dynamics of Influenza A (H5N1) virus protein sequence diversity

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Abd Raman H. S., Tan S., August J. T., Khan A. M.

PEERJ, vol.7, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 7
  • Publication Date: 2020
  • Doi Number: 10.7717/peerj.7954
  • Journal Name: PEERJ
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, EMBASE, Veterinary Science Database, Directory of Open Access Journals
  • Keywords: H5N1, Influenza virus, Sequence diversity, Variants, Fitness-selection, Dynamics, EPIDEMIOLOGY, CONSERVATION, VARIABILITY, GENERATION, RESPONSES, VACCINES
  • Bezmialem Vakıf University Affiliated: No

Abstract

Background. InfluenzaA(H5N1) virus is a global concern with potential as a pandemic threat. High sequence variability of influenza A viruses is a major challenge for effective vaccine design. A continuing goal towards this is a greater understanding of influenza A (H5N1) proteome sequence diversity in the context of the immune system (antigenic diversity), the dynamics of mutation, and effective strategies to overcome the diversity for vaccine design.